The 29-year-old is set to take on Albert Ramos-Vinolas at the Aleksandar Nikolic Arena in Belgrade as the Serbians host a Spanish side without world number five Rafael Nadal.

This match will be followed up by the second singles rubber between Viktor Troicki and Pablo Carreno Busta.

Djokovic, part of Serbia’s Davis Cup winning team in 2010, said that, although he is aware he is the highest ranked player featuring in any of the World Group quarter-finals, it is not all about how he performs on the court.

He also urged his country’s supporters to cheer them on during the tie.

"The Davis Cup is never about one player in any team and I hope fans in Serbia are aware that they always ought to come and support their country no matter who takes centre stage on the court," Djokovic said.

"It is not carved in stone that we will stay in the World Group forever, hence we need home crowd support more than ever in our quest to reach the semi-finals this term.

"It’s always special to play in Belgrade and Serbia in general, as it’s a rare opportunity to get together and win for our country, as well as play quality tennis in front of our fans."

In the other quarter-finals, Italy, who knocked out last year’s champions Argentina in the first round, will travel to the Spiroudome de Charleroi to take on Belgium.

Great Britain, the team who beat the Belgians to the 2015 title, head to the Kindarena in Rouen for their match with France.

The visitors will be without world number one Sir Andy Murray as he recovers from an elbow injury.

France are unable to call on the services of their top two players, Jo-Wilfried Tsonga and Gael Monfils, although they do feature world number 17 Lucas Pouille in their line-up.

An Australian side containing Nick Kyrgios, ranked 16th in the world rankings, host the United States at the Pat Rafter Arena in Brisbane in the other quarter-final.

The US head to Australia with world number 15 Jack Sock in their squad along with John Isner.

Matches are due to be completed on Sunday (April 9).