Harrison, former chief executive officer at Gala Coral Group and finance director at Ladbrokes, has wide experience of the sectors having previously worked at Bass and Grand Metropolitan.
"I am well aware of the busy agendas facing sport, leisure, hospitality and tourism as the new coalition Government settles in and as London 2012 approaches," he said.
"I look forward to doing everything I can to ensure that BISL continues to grow its membership and remains the 'go to' organisation for government on sport and leisure issues."
BISL chairman David Teasdale said: "We are in new political times, with a coalition Government still finding its way, and a tough recession.
"It is vital for BISL to continue to represent its members - and the industry - effectively in this difficult environment.
"I am delighted that Dominic has agreed to join BISL and take forward the key developments for 2011."
BISL sees the appointment as a key investment that will deliver enhanced value to members during 2011.
It is also investing in research and further projects to strengthen the sport and leisure case to government.
It is arguing for new public narratives on gaming, is against the new licensing proposals, and is trying to secure better public policies on employment, property, planning, carbon reduction and sport.